Advances in Thrombosis and Hemostasis

Advances in Thrombosis and Hemostasis

Hemostasis, the arrest of bleeding, requires a finely tuned balance between clot formation and clot degradation. Platelets provide the first line of defense when vascular integrity is compromised. They home to the site of injury where they adhere to the damaged vessel wall, become activated and aggregate to form a platelet plug. The second line of defense involves the strengthening and stabiliz...

Recent Advances in Thrombosis and Hemostasis - Part I.

The burden of thrombotic diseases is heavy on the world population. It is widely known that coronary artery disease is amajor cause of death but many laymen do not know that the mortality is mediated by thrombosis on a ruptured plaque. It is also lesswell-known that stroke is commonly the result of a thrombus that might have embolized from the heart or the carotid artery or was sometimes genera...

Thrombosis and Hemostasis

We recently demonstrated that blockade of the platelet adhesion receptor glycoprotein (GP) Ib protects mice from ischemic stroke. Although von Willebrand factor (VWF) is the major ligand for GPIb , GPIb can engage other counterreceptors on endothelial cells, platelets, and leukocytes (eg, Mac-1 or P-selectin) potentially involved in stroke outcome. To further analyze whether VWF is of particula...

Thrombosis and Hemostasis

1Inserm, Unite 872, Centre de recherche des Cordeliers, Paris, France; 2Université Pierre et Marie Curie-Paris 6, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; 3Université Paris Descartes, Unite Mixte de Recherche S 872, Centre de recherche des Cordeliers, Paris, France; and 4Department of Drug Discovery and Development, Italian Institute of Technology, Geno...

[Hemostasis and thrombosis].